a16z Show

a16z Show

The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

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Five episodes worth starting with, and whether episode 1 is one of them.

Episodes (500)

Why Companies Are Becoming a Series of Loops | Anish Acharya on Lenny’s Podcast

Sep 12, 2026

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What It Takes to Build a Startup | Andrew Chen & Matt Perault

Sep 11, 2026

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How AI Is Rewriting the Power Law of Venture Capital

Sep 10, 2026

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Who Grades the AI Models? | Ben Horowitz & Rayan Krishnan

Sep 9, 2026

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OpenAI Researchers on the Future of Mathematical Reasoning

Sep 8, 2026

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Can Open Source Keep AI Power From Concentrating?

Sep 7, 2026

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Your AI Doctor Is Coming | Julie Yoo

Sep 6, 2026

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Aaron Levie on Why Open AI Wins

Sep 5, 2026

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Fei Fei Li: The Race to Build World Models For AI

Sep 4, 2026

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The $100B Niches Hiding Inside Payments

Sep 3, 2026

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Inside Moderna’s Personalized Cancer Vaccine

Sep 2, 2026

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Daniel Litt: The Mathematician's Guide to AI

Sep 1, 2026

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Gavin Baker: Why AI Demand Is Outrunning Compute Supply

Aug 31, 2026

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Why a16z Launched the Machine Age Fund | Jen Kha

Aug 30, 2026

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Why 1,200 AI Agents Started Working Together | Ryan Greenblatt

Aug 29, 2026

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The Infrastructure Behind the Machine Age

Aug 28, 2026

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Inside Cursor: The Anatomy of a Generational Startup

Aug 27, 2026

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The State of AI: Macro, Apps, and Consumer

Aug 26, 2026

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The New Economics of AI | Martin Casado & Steven Sinofsky

Aug 25, 2026

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Why Medical AI Needs a Referee | Protege's Engy Ziedan

Aug 24, 2026

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Martin Casado on Where the Value Is Going in AI

Aug 22, 2026

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How Microsoft Is Securing the Agentic Enterprise | Aaron Zollman

Aug 21, 2026

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How Global Networks Are Reshaping Startup Success

Aug 20, 2026

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How Whatnot Built a Global Marketplace

Aug 19, 2026

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How Do You Defend Against AI That Can Hack?

Aug 18, 2026

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Stripe’s AI Strategy: Build More, Not Less

Aug 17, 2026

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Ben Horowitz and Travis Kalanick on Building Again

Aug 14, 2026

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The Two Ways to Sell AI: Lighthouse or Landgrab?

Aug 13, 2026

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Garry Tan on Taste, Agents and Founder Ambition

Aug 12, 2026

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The CISO Playbook for AI Agents | Datadog

Aug 11, 2026

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How Kavak Rebuilt Itself Around AI Agents | Alejandro Maza Ayala

Aug 10, 2026

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The Reality of AI-Powered Cyberattacks | Truffle Security & Socket

Aug 7, 2026

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How Open-Source AI Became Critical Infrastructure

Aug 6, 2026

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Three Startups Reinventing Critical Infrastructure

Aug 5, 2026

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OpenAI's Joshua Achiam: Did We Already Reach AGI?

Aug 4, 2026

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Ruby Thelot on Internet Culture, AI, and the Future of Taste

Aug 2, 2026

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Marc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation

Aug 1, 2026

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Decagon’s Playbook for Building Enterprise AI Applications

Jul 31, 2026

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AI for America's Small Businesses | Lassie

Jul 30, 2026

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AI Micro Dramas, Generative Media, and the Future of Creativity

Jul 29, 2026

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Fei-Fei Li on Spatial Intelligence and Robotics

Jul 28, 2026

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Steven Sinofsky: AI Doesn't Need New Rules Yet

Jul 27, 2026

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Ben Horowitz: The Fight Over Open Source AI

Jul 26, 2026

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Sriram Krishnan on Open Source AI's Biggest Week Yet

Jul 24, 2026

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Building the Physical AI Stack | Travis Kalanick on TBPN

Jul 23, 2026

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Travis Kalanick Is Back | Building the Future of Industrial AI

Jul 22, 2026

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Why Physical AI Is the Next Frontier | Applied Intuition

Jul 21, 2026

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Hugging Face's CEO on Open Source AI, Model Routing, and the Future of Competition

Jul 20, 2026

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Amjad Masad on Going Direct, Building Replit, and the Future of Software

Jul 17, 2026

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Replay 2025: David Sacks on AI, Crypto, and America's Technology Future

Jul 16, 2026

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