a16z Show
a16z Show

Why America’s Health Crisis Is an Incentive Problem

February 4, 2026

AI Summary

5 min read

🎙️ The Voices & The Context

  • The Format: A focused interview with host Eric interviewing entrepreneur Justin Mares, blending personal anecdotes, data-driven rants on health crises, and business insights.
  • The Key Players:
    • Guest: Justin Mares, founder/CEO of TrueMed (and prior Kettle & Fire bone broth); obsessed with health optimization, built companies around lifestyle fixes; interesting for exposing "secrets" like environment over pills.
    • Host: Eric (A16Z podcast style), sharp questioner pushing on policy, psychedelics, diets.
  • The Vibe: Intense and educational—urgent alarm on America's sickness epidemic, optimistic on fixes like TrueMed, with witty banter (e.g., Amish "doom scrolling," smashing phones).

🗝️ Key Themes & Topics

The episode dives into America's chronic disease crisis as an environmental mismatch, blaming food systems, subsidies, and policy; explores prevention over treatment via TrueMed; critiques mental health silos; touches emerging ideas like peptides and consciousness.

Continue reading the full summary in the app — free to try.

Read Full Summary →

Free • No credit card required

What you'll learn

  • 1 (00:00) **🎙️ Introduction: Justin Mares**
  • 2 (02:01) **Justin's Health Obsession Journey**
  • 3 (03:16) **Modern Environment vs. Past Health**
  • 4 (05:00) **Turning Point: 1970s Food System Shift**
  • 5 (06:53) **Crop Subsidies as Root Cause**
  • 6 (09:17) **Ozempic and GLP-1 Limitations**
  • 7 (10:49) **Food Pyramid Updates and Opportunities**

+ Full timestamped outline available in the app

Show Notes

a16z general partner Erik Torenberg speaks with Justin Mares, founder and CEO of TrueMed. They discuss why American health outcomes are so poor compared to the rest of the developed world, how crop subsidies created a food system that "systematically outputs unhealthy people," and what it would take to treat the chronic disease crisis as a national security issue. Mares explains how TrueMed allows people to spend tax-free HSA and FSA dollars on lifestyle interventions like gym memberships, sleep aids, and healthier food—and why he believes this could redirect hundreds of billions of dollars toward prevention. They also explore the case for psychedelics as mental health therapy and why peptides could disrupt the pharmaceutical industry.

 

Resources:

Follow Justin Mares on X: https://x.com/jwmares

Follow TrueMed on X: https://x.com/truemed

 

Stay Updated:

If you enjoyed this episode, be sure to like, subscribe, and share with your friends!

Find a16z on X: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX

Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see http://a16z.com/disclosures.

Stay Updated:

Find a16z on X

Find a16z on LinkedIn

Listen to the a16z Show on Spotify

Listen to the a16z Show on Apple Podcasts

Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the com

a16z Show

More from this podcast

a16z Show →