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How to Build Strength, Muscle Size & Endurance Dr. Andy Galpin

August 29, 2026

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5 min read

How to Build Strength, Muscle Size & Endurance

Dr. Andy Galpin, a professor of kinesiology at California State University, Fullerton, has worked with everyone from professional athletes to recreational exercisers. In this conversation with Andrew Huberman, he laid out a systematic framework for understanding nine distinct adaptations you can get from exercise—and how to pursue them without getting in your own way.

The Nine Adaptations and the Modifiable Variables

Galpin starts with a high-level map. There are nine things you can train: skill, speed, power, strength, hypertrophy (muscle size), muscular endurance, anaerobic power (roughly 30 seconds to two minutes of max effort), VO2 max (three to twelve minutes of hard work), and long-duration endurance (30-plus minutes of sustained effort). Some of these overlap; others push against each other. Pursuing one can sacrifice another.

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What you'll learn

  • 1 (10:45) **The Nine Adaptations of Exercise** - Dr. Galpin introduces the nine distinct physiological adaptations you can get from exercise, starting with skill, speed, and power.
  • 2 (17:52) **The Modifiable Variables for Training** - A framework for understanding how to change any workout to get a specific result, starting with the concept that exercise choice alone does not determine adaptation.
  • 3 (22:52) **Defining Intensity and Volume** - A practical explanation of how to determine your working weight without a formal one-rep max test, using repetition conversion charts or "reps in reserve."
  • 4 (26:42) **Muscle Soreness as a Training Metric** - A critical look at why soreness is a poor proxy for workout quality and how to use it to gauge recovery instead.
  • 5 (28:52) **Strength Training: The "Three to Five" Concept** - A specific, actionable protocol for building strength, including exercise selection, intensity, and rest intervals.
  • 6 (33:28) **Strength vs. Hypertrophy: The Neural vs. Volume Driver** - A deep dive into why you can train for strength daily but need more recovery for hypertrophy, and how the nervous system is the primary early driver of strength gains.
  • 7 (58:16) **Hypertrophy: Rep Ranges and the Mind-Muscle Connection** - A detailed look at the broad effective rep range for muscle growth and the role of intentionality during a lift.

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Show Notes

How to Build Strength, Muscle Size & Endurance  Dr. Andy Galpin

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