Anthropic’s Mythos is a cyber-weapon, so you can’t have it | E2273

April 8, 2026

AI Summary

5 min read

🎙️ The Speakers & Context

The Format: Host discussion with two expert guests and a live call-in segment.
The Key Players:
- Jason Calacanis: Host, veteran startup investor and angel. Provides the "game theory" and macro-strategic lens.
- Alex Wilhelm: Co-host, tech analyst. Provides the data-driven, market-timing perspective.
- Rob May (Guest): CEO of Neurometric (SLM builder). Credibility: Serial entrepreneur (Backupify), early AI thinker, building the "anti-frontier" model thesis.
- Gianni (Guest): Creator of "Death by Claude." Credibility: Founder who was disrupted by Anthropic, now building a defensibility audit tool.
The Vibe: Combative, strategic, and darkly humorous. The hosts are in "war room" mode, debating existential threats and market shifts.

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What you'll learn

1 (00:00) **🎙️ Introduction: Rob May (Neurometric) & Guest Gianni (TabTab.ai)**
2 (00:52) **Anthropic Mythos: The "Unreleasable" Model**
3 (05:38) **Guest Deep Dive: Rob May on the Mythos Announcement**
4 (08:01) **Video Reaction: Anthropic's Dario on Withholding Mythos**
5 (10:53) **The AI Arms Race: Anthropic vs. OpenAI & National Security**
6 (14:53) **Polymarket Analysis & The Timeline to Release**
7 (17:50) **The "Manhattan Project" Proposal & Talent War**

+ Full timestamped outline available in the app

Show Notes

Anthropic just built a model so dangerous, they’re not even going to release it (for now). On TWiST, Jason, Alex, and Neurometric CEO Rob May discuss whether or not this is just another frontier model or a potential weapon of mass internet destruction.

Claude Mythos Preview is already in the hands of over 40 Anthropic partners — including Nvidia, Apple, Amazon, Microsoft, and Google — as part of its “Project Glasswing” security council.

Together, they’ll test how quickly and easily the model can thwart today’s most elite cybersecurity protocols, and try to develop fresh protocols to keep our most sensitive and critical software systems safe and intact. Once Mythos or a similarly powerful model hits the streets… it’s all over!

Plus, we’re checking out the real-time SaaSpocalypse monitor Death By Clawd, and chatting with its creator, Gyani, about how it feels to have your startup one-shotted by Anthropic’s latest model.

Guests

Rob May: https://x.com/robmay

Neurometric: https://www.neurometric.ai/

Neurometric SLM Marketplace: https://marketplace.neurometric.ai/

Death by Clawd: https://deathbyclawd.com/

Nick O’Neill: https://x.com/chooserich

This Week In Startups is made possible by:

LinkedIn Jobs - LinkedIn.com/twist

Grasshopper Bank - Grasshopper.bank/twist

Render - Render.com/twist

Plaud - https://Plaud.ai/twist

Today’s show:

Timestamps:

0:00 Anthropic's new, powerful 'Mythos' model

3:50 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!

5:26 Neurometric's Rob May joins the show

10:04 Sam Altman's talent exodus

10:50 Render - Go to https://render.com/twist to apply for the Render Startup Program. You'll get anywhere from $500 to $100,000 in free credits.

11:50 Has Anthropic Passed OpenAI?

15:44 When will Claude release Mythos? Polymarket: https://polymarket.com/event/claude-mythos-released-by

18:32 The AI race turns existential

19:16 Would Anthropic's model give the CIA the ability to hack a foreign government?

20:04 Grasshopper Bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.

21:19 Should AI be nationalized?

29:43 Subsidizing secret AI development.

30:15 LinkedIn Jobs - Hire ri