Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan

April 3, 2026

AI Summary

5 min read

Dr. Nathan Bryan explains how everyday habits disrupt nitric oxide (NO) production, a key molecule for blood vessel dilation, blood pressure control, wound healing, and exercise benefits. In this clip from The Diary of A CEO, host Steven Bartlett discusses the oral microbiome's role in converting dietary nitrates to NO, and how common products like mouthwash and fluoride toothpaste eliminate these gains.

Avoiding Disruptors to Oral NO Production

Fluoride in toothpaste poses risks without benefits, per National Toxicology Program data cited by Bryan. It acts as a neurotoxin, lowering children's IQ by up to seven points, impairing thyroid function, and getting absorbed systemically even without swallowing due to its small molecular size. Labels warn to call poison control if swallowed and recommend only a pea-sized amount—yet most people use 10-20 times more. Bryan advises switching to non-fluoridated toothpaste.

Continue reading the full summary in the app — free to try.

Read Full Summary →

Free • No credit card required

Listen to Audio Summary Open in App

What you'll learn

1 (01:04) **Avoid Fluoride in Toothpaste** - Dr. Bryan warns fluoride is a neurotoxin with no benefits, lowers IQ, shuts down thyroid; use pea-sized amount or switch to non-fluoridated
2 (02:57) **Tongue Scraping Benefits** - Ancient practice increases oral microbiome diversity for better health; use copper scraper to till tongue biofilm like soil for garden
3 (04:53) **Dental Hygiene Practices** - Routine hygienist cleanings good for gums/teeth mineralization, but refuse fluoride rinses
4 (05:31) **Mouthwash Erases Exercise Benefits** - Kills oral bacteria needed for nitric oxide (NO) from diet/exercise, leading to high blood pressure
5 (06:27) **Hormones, Exercise, and NO Link** - Testosterone/estrogen stimulate NO; low levels cause ED, poor cardio benefits
6 (08:13) **Diet to Boost NO: Avoid Sugar** - Sugar glycates enzymes, sticks like glue (e.g., HbA1c), halts NO production; causes diabetic complications
7 (11:30) **NO for Wound Healing** - Demo of topical NO generator (mix two pumps) increases blood flow, stem cells, kills infection

+ Full timestamped outline available in the app

Show Notes

Dr Nathan Bryan is a leading nitric oxide researcher and biochemist, known for his work on cardiovascular health, blood pressure, and human physiology.

In this moment, he reveals a surprising and controversial insight: everyday oral health habits like mouthwash and toothpaste may be disrupting your oral microbiome and blocking nitric oxide production. He explains how this directly impacts blood pressure, circulation, and even reverses the benefits of exercise - unpacking the science behind one of the most overlooked systems in human health.

Listen to the full episode here:

Spotify: https://g2ul0.app.link/JbS4DZVXV1b

Apple: https://g2ul0.app.link/3WbhlB1XV1b

Watch the Episodes On YouTube:
https://www.youtube.com/c/%20TheDiaryOfACEO/videos

Nathan Bryan: https://n1o1.com/about-dr-nathan-bryan/?srsltid=AfmBOooOFqsJRAP7whrtk26AsE0bI1-NrNlxbJVP-uhBoHYLuAEPy673