From First Principles
From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.
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Episodes (61)
What’s Next in Science? Nobel Prizes, Space Missions & More (EP 57)
Sep 14, 2026
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The Yak Mutation That Could Help Repair the Brain (EP 56)
Sep 7, 2026
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Why Spin Qubits Will Win the Quantum Race (Part 2) (EP 55)
Aug 31, 2026
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How Quantum Computing Actually Works (Part 1) (EP 54)
Aug 20, 2026
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What Claude Actually Did to the Riemann Hypothesis (EP 53)
Aug 14, 2026
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The Amazon’s Hidden Civilization (One Year Anniversary) (EP 52)
Aug 6, 2026
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The Tech Elon Has Been Waiting For (EP 51)
Jul 31, 2026
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AI Breaks a 90-Year Math Problem, Life’s Alphabet in Space, and Science Funding (EP 50)
Jul 23, 2026
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FIFA Data Scientists Explain Match Momentum (EP 49)
Jul 17, 2026
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Black Hole Movies, Digital Heart Twins, and World Cup Tech (EP 48)
Jul 14, 2026
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America 250: The Breakthroughs That Built American Science — Part 2 (EP 47)
Jul 3, 2026
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America 250: The Breakthroughs That Built American Science — Part 1 (EP 46)
Jul 2, 2026
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The Physics of the World Cup: VAR, Smart Balls, and Soccer Aerodynamics (EP 45)
Jun 29, 2026
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New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics) (EP 44)
Jun 26, 2026
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Dr. Michael Blanton on Open Data, Galaxy Surveys, and the Future of Astronomy (EP 43)
Jun 4, 2026
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How Scientists Actually Study Dark Matter (EP 42)
May 21, 2026
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Dr. John Mulchaey on Carnegie Science and the Future of Astronomy (EP 41)
May 13, 2026
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Ant Scans, Lunar Chickpeas, Hidden Galaxies & Superconductivity (EP 40)
Apr 29, 2026
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The Prometheus Constellation: Dramaturgical and Scientific Analysis of the Physicists in Oppenheimer (EP 39)
Apr 21, 2026
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Harder Than Diamond? The New Hexagonal Diamond Breakthrough (EP 38)
Apr 15, 2026
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Artemis II: Deep Dive on the Moon Flyby, Earthset, and Reentry (EP 37)
Apr 9, 2026
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Artemis II, Claude Code Leak, iPhone Spyware & Project Hail Mary (EP 36)
Apr 3, 2026
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Can AI Help Wake Coma Patients? The Science of Consciousness (EP 35)
Mar 31, 2026
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AI Cancer Vaccines, Strange Fish, Ketamine, and Ancient Life (EP. 34)
Mar 27, 2026
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Can Human Neurons Really Play Doom? The Science Behind Wetware (EP. 33)
Mar 24, 2026
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5,000-Year-Old Bacteria, Solar Storms, Dogs, and Meta’s AI War (EP. 32)
Mar 20, 2026
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Optovolution: Teaching Proteins to Think Like Computers (EP. 31)
Mar 18, 2026
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Can We Stop an Asteroid? The Physics Behind NASA’s DART Mission (EP. 30)
Mar 16, 2026
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Astrobiology’s Biggest Survival Test + A Vaccine Against Everything? (EP. 29)
Mar 12, 2026
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Dark Galaxies, Fuzzy Dark Matter, and an Alzheimer’s Breakthrough (EP. 28)
Mar 4, 2026
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Dream Engineering, the Proton Radius Puzzle, and an ALS Breakthrough (EP. 27)
Feb 26, 2026
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Winter Olympics Deep Dive: Ice Physics, Performance Pressure, and Climate Change (EP. 26)
Feb 18, 2026
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Plants, Quantum Sensors, and Predicting Cancer Evolution (EP. 25)
Feb 10, 2026
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Artemis II, Apollo, and the Physics of Going Back to the Moon (EP. 24)
Feb 4, 2026
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JWST’s “Little Red Dots,” TimeVaults, and the Dawn of Math (EP. 23)
Jan 27, 2026
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Cloud9 Dark Matter Halo, Jellyfish Sleep, and String Theory Hidden in Nature (EP. 22)
Jan 20, 2026
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Roman Concrete, Brain “Cognitive Legos,” DeepSeek, and Econophysics (EP. 21)
Jan 12, 2026
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The Physics Behind Fusion’s Biggest Problem (Season Finale) (EP. 20)
Dec 23, 2025
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The Race to the Double Helix — Watson, Crick, Franklin & the Real Story of DNA (EP. 19)
Dec 4, 2025
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3I/ATLAS Explained, Forensic Fingerprints & Alzheimer’s Breakthrough (EP. 18)
Nov 27, 2025
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Hypersonic Physics, Deep Sea Life & Princeton’s Millisecond Qubits (EP. 17)
Nov 22, 2025
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Octopus Camouflage, Orcas vs. Sharks, Civet Coffee & Sub-Diffraction Telescope Tech (EP. 16)
Nov 13, 2025
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AI-Generated Genomes, Retinal Implants, and Palomar’s Mystery Lights Explained (EP. 15)
Nov 6, 2025
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Chen Ning Yang — The Man Who Unlocked Symmetry (EP. 14)
Oct 31, 2025
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Portable Muon Beams, Sodium Batteries, and the Secret to Long Life (EP. 13)
Oct 23, 2025
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From Princeton to the Nobel Prizes — How FFP Started + 2025 Nobel Recap (EP. 12)
Oct 15, 2025
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From Cells to Circuits to Crystals — 2025 Nobel Prizes Unpacked (EP. 11)
Oct 9, 2025
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AI Supercharges CRISPR & LIGO (Nobel Prize Week Preview) (EP. 10)
Oct 2, 2025
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China’s AI Breakthrough, Time Crystals, Hidden Viruses, & Brightest Cosmic Signal (EP. 9)
Sep 23, 2025
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Strongest Evidence for Alien Life? (Mars, K2-18b & JWST) (EP. 8)
Sep 16, 2025
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