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5 min readAn Alzheimer's breakthrough?
There are videos coming out of China that look almost surreal. A 76-year-old man with late-stage Alzheimer's disease, who could barely communicate, sits down unassisted after an experimental surgery. He speaks coherently. He recognizes family members. In one clip, he's singing—which, as one observer notes, requires higher brain function than just talking. After decades of false starts, dead ends, and a disease that doesn't just kill you but steals your identity, these videos have generated enormous attention. But are they real? And what do they actually mean for the millions of people living with Alzheimer's?
The dark years
Dylan Scott, a senior correspondent at Vox who has covered Alzheimer's for years, describes where the field stood five years ago as "a really dark time." Decades had passed since a new treatment was approved. The only available drugs gave patients a few months of symptom relief before the disease resumed its relentless course. Then the FDA approved a controversial drug against the advice of its own scientific advisors, who said the evidence for effectiveness was weak and the risk of serious side effects was high. The approval created emotional whiplash: hope that something could finally slow the disease, followed almost immediately by that hope being yanked away. Scientists were questioning whether they had Alzheimer's co
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What you'll learn
- 1 (01:22) **Shocking Videos from China** - Dylan Scott introduces experimental Alzheimer's surgery videos showing dramatic patient improvements.
- 2 (02:33) **The Dark History of Alzheimer's Research** - Dylan Scott describes the bleak landscape he encountered when he first started covering Alzheimer's five years ago.
- 3 (03:28) **Dylan Scott's Surprising New Message** - Scott explains why he now says "believe the hype" about Alzheimer's breakthroughs.
- 4 (06:18) **How Alzheimer's Works (As Far As We Know)** - Scott gives a basic explanation of the prevailing theory of Alzheimer's disease.
- 5 (07:53) **Preventing Alzheimer's Before It Starts** - Scott discusses new insights into risk reduction and surprising preventative treatments.
- 6 (10:15) **New Drugs That Actually Slow Decline** - Scott explains the two new FDA-approved drugs, Lecanemab and Donanemab.
- 7 (11:37) **The Experimental Chinese Surgery** - Scott describes the surgery that creates a drain in the brain to clear amyloid plaque and tau proteins.
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Guests on this episode
Show Notes
The past few months have been full of Alzheimer's optimism: new ideas that could prevent the disease from taking hold, medications that seem to slow it down, and an experimental surgery that might even be able to reverse its progression. It's a lot of hype. Should we believe it?
Guest: Dylan Scott, senior correspondent at Vox
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