The Shawn Ryan Show
The Shawn Ryan Show

#330 Dr. Craig Koniver - The Godfather of Peptides

August 13, 2026

AI Summary

5 min read

When Dr. Craig Koniver was 46, a radiologist told him to go to the emergency room immediately. He had a portal vein thrombosis—a blood clot in the main vein feeding his liver—and the CT scan also showed a mass on his pancreas. While waiting for an MRI during the COVID lockdown, he was left alone for two hours and had what he describes as an experience of total peace with God. The next morning, the MRI showed the mass was gone. Koniver is careful about how he tells this story. He does not insist it was a miracle, but he does not rule it out either. “I’m pragmatic, I’m practical,” he says. “Maybe it was an artifact. But I wouldn’t put it on the report.” What he is certain about is that the experience reshaped how he practices medicine.

Five things for a 45-year-old who wants 40 more good years

Asked for his top-five protocol, Koniver starts with something that sounds soft but that he treats as the hardest problem in his practice: sleep. He is not against sleep medications like Ambien, but he questions whether they deliver deep restorative sleep. Instead he recommends intermittent use of natural compounds like theanine and glycine, and points to peptides that support the circadian rhythm.

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What you'll learn

  • 1 (01:07) **Welcome & Opening Gift Exchange** - Shawn welcomes Dr. Craig Koniver and they exchange pleasantries, noting they've worked together for two years after being connected by Andrew Huberman.
  • 2 (03:55) **Patreon Question: Top 5 for a 45-Year-Old** - Dr. Koniver answers a listener's question on the five most important things for a healthy 45-year-old man to do for the next 40 years.
  • 3 (06:48) **Hormones, Peptides & The "Biohacker Influencer" Trap** - Dr. Koniver continues his top-five list with hormonal optimization and peptides, then warns against the stressful pressure to do everything.
  • 4 (09:11) **Cold Plunge, Sauna & Diet: Overhyped or Essential?** - Dr. Koniver shares his personal take on cold plunge and sauna, advocating for direct experience over rigid protocols.
  • 5 (10:52) **The Hidden Dangers in Water** - Dr. Koniver explains why filtering and remineralizing water is critical, and how declining mineral content in water mirrors the decline in human health.
  • 6 (14:36) **Understanding Stress Through Biological Testing** - Dr. Koniver explains how he uses urine and saliva hormone tests to understand a patient's stress response and the biological mechanisms behind their thoughts.
  • 7 (20:18) **Dr. Koniver's Near-Death Experience: A Portal Vein Thrombosis** - Dr. Koniver recounts the harrowing story of being diagnosed with a life-threatening blood clot and a mass on his pancreas in 2020.

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Show Notes

Dr. Craig Koniver is a physician who rebuilt his entire practice after a near-fatal portal vein thrombosis at age 46 exposed the failures of conventional medicine. A former Old World Archaeology and Art major, he pairs ancient healing traditions with modern precision medicine and with over 50,000 peptide treatments administered, he has more direct clinical experience in biological optimization than any physician in America. His patients include Navy SEALs, Fortune 500 CEOs, professional athletes, world-famous actors, supermodels, politicians, and veterans who move from depletion to sovereign performance.


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Dr. Craig Koniver Links:

Instagram - https://www.instagram.com/koniverwellness

Website - https://www.koniverwellness.com


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