Should Everyone Be On GLP-1s? + Other Longevity Secrets Your Doctor Won't Tell You

October 14, 2026

AI Summary

5 min read

GLP-1s, Testosterone, and the Five Biomarkers That Predict Your Health Future

Dr. Florence Comite, an endocrinologist who trained at the NIH and spent 25 years on the faculty at Yale, argues that nearly every person walking the earth today has a disorder of carbohydrate metabolism. "I haven't met one person with an optimal fasting sugar, fasting insulin, or hemoglobin A1C in combination," she says. "Not one." The reason is evolutionary: our ancestors were selected for survival during famines, which means we are genetically programmed to store energy efficiently. But now we live twice as long as any humans before us, and that same genetic programming causes glucose to circulate in our systems and damage every organ it touches — skin, brain, heart, kidneys, eyes. This is the underlying problem that GLP-1 drugs address, and it is why Comite calls them "the antibiotics of the 21st century."

The Five Biomarkers That Tell You Where You Stand

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What you'll learn

1 (00:25) **Guest Introduction & GLP-1 Framing** - Dr. Florence Comite, leading endocrinologist from Yale/NIH, is introduced as the rare expert with both credentials and cutting-edge knowledge.
2 (02:49) **Why GLP-1s Work: The Universal Metabolic Problem** - Dr. Comite explains that almost everyone has a disorder of carbohydrate metabolism inherited from famine-surviving ancestors.
3 (05:55) **Dr. Comite's Personal GLP-1 Experience & Safety Concerns** - She shares her own struggle with nausea on GLP-1s but notes her kidney function improved on Mounjaro.
4 (08:46) **The Five Critical Biomarkers** - Dr. Comite lists the five blood tests that help evaluate whether a GLP-1 is right for you.
5 (11:50) **How to Get These Tests & The CGM** - Practical advice on requesting these biomarkers from your doctor and using a continuous glucose monitor (CGM).
6 (12:27) **Two Truths and a Lie: Muscle, Peaking, and a Supplement** - A quick game that reveals muscle is the organ of longevity and a specific supplement reverses aging eyesight and gray hair.
7 (14:52) **Sarcopenia, Muscle, and Testosterone** - How to protect muscle while on GLP-1s and why testosterone is critical for both men and women.

+ Full timestamped outline available in the app

Show Notes

If you want to feel better now and live as long as you possibly can, you're going to want to listen to this episode (and you’re going to want to share it with everybody that you love).

Today's guest is one of the only people in the world who has insane credentials and new cutting edge scientific knowledge that nobody else is sharing. Dr. Florence Comite is one of the leading endocrinologists in the world. She trained at the NIH, spent 25 years on the faculty at Yale and founded their Women's Health Research Center.

We get into everything from why she thinks GLP-1s are the antibiotics of the 21st century, to why a lot of us should be starting testosterone in our 30s, to the five biomarkers you can ask your doctor for to get a real picture of your health.

🎧 What you’ll learn:

• Who should consider taking a GLP-1

• Why every woman may need testosterone in their 30s

• Whether you should sleep in or go to the workout

• The 5 biomarkers that reveal what's going on in your body

• The formula that lets you enjoy sweets without spiking your blood sugar

• A supplement Dr. Comite has taken for 15+ years that reversed her need for reading glasses and her gray hair

• The 2 minute daily habit that can cut your heart attack risk

• The hidden danger of living near a golf course (this one's shocking!)

• The $30 wearable that can teach you more about your body than most doctor's visits

• An expensive longevity treatment she says actually works and one that’s a total waste of money

If you liked this episode, check out “GLP-1s: The New Science Transforming Hormones, Weight Loss, Brain Health, and Beyond”

• Listen/Watch on Spotify

• Listen on Apple

For more from Dr. Florence Comite:

• Instagram:https://www.instagram.com/drflorencecomite/?hl=en

• Website: https://www.comitemd.com/

• Book: https://www.theinvinciblebook.com/

Ready to uplevel every part of your life? Order Liz’s book 100 Ways to Change Your Life: The Science of Leveling Up Health, Happiness, Relationships & Success now!

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