The Dr. Josh Axe Show
The Dr. Josh Axe Show

The Testosterone, Weight Loss & Hormone Lies Your Doctor Never Told You | Brigham Buhler

October 1, 2026

AI Summary

5 min read

In a recent episode of The Dr. Josh Axe Show, Brigham Buhler, a clinician and founder of the cash-pay clinic and pharmacy network Ways2Well, laid out a stark argument: the American healthcare system is not designed to keep you healthy. Buhler, who has appeared on the Joe Rogan podcast and testified before the FDA on peptide regulation, spent the conversation dissecting the financial incentives that drive poor patient outcomes, from the insurance industry’s grip on prescription drug pricing to the suppression of advanced therapies like plasma exchange and peptides.

The Insurance Model Is Designed for Emergencies, Not Health

Buhler’s central claim is that health insurance in the United States functions more like car insurance than a vehicle for wellness. "It's great if you total the car," he says. "But if you're expecting it to rotate the tires, change the oil and maintain the vehicle, you are going to be sorely disappointed." The problem, he explains, is structural. In the 1990s, the five largest insurance companies captured the Pharmacy Benefit Managers (PBMs)—entities originally created to negotiate drug prices down. Instead, PBMs began negotiating prices up, because the insurance companies receive rebates from pharmaceutical companies on each prescription. "In any other field, we would call that a kickback," Buhler says.

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What you'll learn

  • 1 (03:56) **Therapeutic Plasma Exchange: Blood Filtration & Detox** - Brigham explains how plasma exchange (plasmapheresis) works and why it's being repurposed for modern wellness.
  • 2 (06:03) **Microplastics, Testosterone & Fertility** - A case study of a man with sky-high microplastics who restored his testosterone and conceived naturally.
  • 3 (07:26) **Why Insurance Blocks the Best Care** - The systemic problem: insurance covers minimal care, not advanced therapies that actually work.
  • 4 (09:46) **The Shift to Cash-Pay & Advanced Testing** - Post-COVID, patients are demanding full blood panels and genetic screening outside the insurance model.
  • 5 (11:36) **MTHFR, Methylation & Personalized Supplementation** - Genetic nuance matters: not everyone tolerates methylated B vitamins or NAD the same way.
  • 6 (13:53) **How Insurance Negotiations Limit Patient Access** - Behind-the-scenes deals between insurers and hospitals suppress genetic testing and other preventive tools.
  • 7 (14:36) **The U.S. Healthcare Paradox** - America spends the most but ranks near the bottom in quality of life; the system is designed for emergencies, not maintenance.

+ Full timestamped outline available in the app

Show Notes

Who decides which treatments you can access—and at what cost? Ways2Well founder Brigham Buhler joins Dr. Josh Axe to discuss pharmacy benefit managers, prescription pricing, and his fight for peptide access. They explore his FDA testimony, the debate over BPC-157 and GLP-1 medications, and his clinic’s use of plasma exchange and ozone therapy.


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