The Plants & Protocol That Clear Eczema & Acne In Weeks | Dr. Barbara Paldus

June 25, 2026

AI Summary

5 min read

Dr. Barbara Paldus, a Stanford-trained PhD and serial entrepreneur, didn't set out to build a biotech skincare company. She set out to help her son, who had severe eczema and later ADHD. Her mother, a Czech medical doctor, threw away the corticosteroid creams and started making home remedies. That moment—and the ancient Irish manuscripts she later discovered—became the foundation of Codex Labs, a company that treats skin conditions like eczema and acne by targeting the skin barrier, the gut microbiome, and the immune system simultaneously. In a recent clinical trial on 80 children with moderate eczema, a protocol of a specialized plant-based lotion, a cold-process soap, and an L-histidine supplement achieved 70% clearance in 100% of children by week four, and 95–97% clearance by week eight—without a single drop of topical corticosteroid.

The Skin as a Multi-Layered System

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What you'll learn

1 (00:55) **Introduction & Host's Thyroid Deep Dive** - Dr. Will Cole introduces the topic of comprehensive thyroid testing, explaining why TSH alone is insufficient.
2 (03:56) **Guest Introduction: Dr. Barbara Paldus** - Dr. Cole introduces Dr. Paldus, a Stanford PhD and serial entrepreneur, and her biotech skincare company Codex Labs.
3 (05:54) **Origin Story: A Son's Eczema Sparks a Mission** - Dr. Paldus shares how her son's eczema and ADHD led her to explore traditional remedies and eventually start Codex Labs.
4 (11:42) **The Skin-Gut Connection Explained** - Dr. Paldus breaks down the multi-layered skin barrier and its communication with the gut microbiome.
5 (16:20) **Outside-In: Skin Microbiome Dysregulation in Acne & Eczema** - Detailed mechanisms of how acne and eczema develop from the skin outward.
6 (20:21) **Inside-Out: The Gut's Role in Skin Inflammation** - How gut dysbiosis and leaky gut drive skin conditions like eczema and acne.
7 (27:45) **The Irish Plants: Comfrey, Calendula & the "Dracula Plant"** - Dr. Paldus details the ancient plants used in Codex's eczema lotion and their mechanisms.

+ Full timestamped outline available in the app

Show Notes

Dr. Barbara Paldus — biotech engineer, founder of Codex Labs Corp, and one of the most rigorous minds in plant-based skin science — joins Dr. Will Cole to break down the full skin-gut-immune axis behind eczema, acne, psoriasis, and rosacea. They cover the five layers of the skin most people don't know exist, the filaggrin protein that eczema patients are missing, and how a combination of 14th-century Irish plants and a Bulgarian resurrection plant was clinically proven to achieve 95–97% eczema clearance in eight weeks with zero topical corticosteroids. Dr. Paldus also walks through the hormonal cascade driving acne, why milk thistle compares favorably to doxycycline, the L-histidine supplement protocol from their pediatric and adult clinical trials, and the launch of Decode Me — the first tele-naturopathy platform integrating functional labs, AI interpretation, and Fullscript. For all links mentioned in this episode, visit www.drwillcole.com/podcast.

Visit codexlabscorp.com and use code WILLCOLE30 for 30% off your first purchase of a 60-day eczema or acne system.

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