The Art of Being Well
The Art of Being Well

The Fine Art Science of Fasting To Tap Into & The Cellular Guardian Angels | Deep Dive

October 8, 2026

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5 min read

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Hi, I'm Dr. Will Cole. Wellness is a sacred art and you are the masterpiece. This is The Art of Being Well.

What's up and welcome to The Art of Being Well, everybody. So we've been peppering these episodes, these health hot take, solo-ish podcast episodes for you all that have been asking for a deep dive on different niche health topics, can we call it that? Very specific granular health topics and get into the weeds of all the fun of different things, right? We talked about AI and healthcare and beyond health AI and humanity in one. I did some solo ones that were also health health takes about trauma and burnout. Yep. And we talked about xenohormesis, which we'll get into the other types of hormesis, like different plant compounds that upregulate cellular healing pathways. And it'll probably be a bit overlap, almost like a part two of that today. So join me today. It's not a fully solo episode. We have Andrea that you all

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What you'll learn

  • 1 (01:05) **Fasting: Trend or Timeless Tool?** - Will and Andrea frame the conversation by addressing whether fasting is just a passing wellness trend.
  • 2 (09:38) **Hormesis: The Dose Makes the Medicine** - Andrea asks Will to explain hormesis and how fasting fits into this broader concept of beneficial stress.
  • 3 (20:01) **Autophagy & The Cellular Guardian Angels** - A deep dive into what happens inside cells during a fast, beyond just fat burning.
  • 4 (24:56) **Beyond Fasting: Other Ways to Activate Autophagy** - Will explains that fasting is not the only way to trigger cellular cleanup.
  • 5 (32:17) **The Full Spectrum of Fasting Benefits** - Andrea pushes Will to explain what fasting does for the body on a cellular level, far beyond weight loss.
  • 6 (38:22) **Fasting and the Gut Microbiome** - Will connects fasting to gut health, a less-discussed but critical benefit.
  • 7 (39:50) **What Can You Actually Have While Fasting?** - The hosts address the common confusion over what is and isn't allowed during a fast.

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Guests on this episode

Dr. Will Cole

Show Notes

Dr. Will Cole sits down with Andrea from his clinical team for a deep-dive Health Hot Take on the myths and truths of fasting - what it actually does on a cellular level, the ancient history behind "the dose makes the poison, the dose makes the medicine," what you can and can't have during a fast, and who should approach it with extra caution. For all links mentioned in this episode, visit www.drwillcole.com/podcast


Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.


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