The Art of Being Well
The Art of Being Well

Mind, Body, and God: A New Kind of Health Conversation | Dylan Gemelli, Dr. Josh Axe & Dr. Will Cole

September 10, 2026

AI Summary

5 min read

“I’ll sleep when I’m dead.” For Dr. Dylan Gemelli, that phrase used to be a badge of honor. A decade spent in the hardcore fitness and bodybuilding world had taught him to push through, rest be damned. But after a cardiac scare—plaque in his arteries and an LP(a) score so high he was told it was impossible to lower—he began to realize that the “all gas, no brakes” approach was running him straight into the ground. That personal reckoning sets the stage for this roundtable conversation between Gemelli, Dr. Josh Axe, and Dr. Will Cole, where the three doctors and clinicians attempt to weave together cellular medicine, spirituality, and practical nutrition into a single, coherent framework for health.

The Cellular Root of Chronic Disease

The conversation’s central argument is that most chronic health problems are not organ diseases but cellular dysfunctions. Dr. Will Cole frames it bluntly: mainstream medicine looks at the thyroid, the gut, or the brain, but “really what it is is actual cellular dysfunction that’s going on here.” The immune system attacking the thyroid in Hashimoto’s, for example, is a downstream effect of confused cells that have lost their sense of identity—a process called dedifferentiation.

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What you'll learn

  • 1 (01:17) **Introducing the Roundtable and the Core Thesis** - Dylan Gemelli kicks off a three-way conversation with Dr. Josh Axe and Dr. Will Cole, setting up the central idea that cellular health is the root of all chronic disease.
  • 2 (03:31) **The Stanford Organ-Aging Study and the "Reversible" Paradigm** - Dr. Will Cole explains a landmark 2023 Stanford study showing that one in five people has an organ aging faster than others, dramatically increasing disease risk.
  • 3 (06:57) **When to Start: The Case for Early Cellular Intervention** - The discussion turns to the age at which people should begin monitoring cellular health, with Josh arguing it starts in infancy.
  • 4 (15:08) **Blood Markers: How to Spot Cellular Dysfunction** - Dr. Will Cole provides a practical guide to the key blood markers that reveal cardiometabolic cellular issues, distinguishing between lab reference ranges and optimal functional ranges.
  • 5 (20:36) **Defining Insulin Resistance: The "Deaf Cell" Analogy** - Dr. Josh Axe breaks down the mechanism of insulin resistance, explaining it as a cellular communication failure.
  • 6 (28:11) **Root Cause: Sleep, Light, and the Circadian Rhythm** - The conversation shifts to the primary drivers of insulin resistance and cortisol dysfunction, with Dr. Josh Axe identifying poor sleep and circadian rhythm disruption as the initial tipping point.
  • 7 (36:00) **The 3 AM Wake-Up: A Cortisol Check Engine Light** - The panel discusses the specific problem of waking up at 3 AM and being unable to fall back asleep, identifying it as a sign of high cortisol and poor vagal tone.

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Guests on this episode

Josh Axe Will Cole

Show Notes

Dr. Will Cole joins forces with Dr. Josh Axe and health coach Dylan Gemelli for the first episode of The Round Table - a new collaborative series releasing across all three of their channels. Over two-plus hours, they go deep on cellular health and the Stanford study most doctors haven't caught up to yet, optimal vs. "normal" lab ranges, the future of peptides, the seed oil debate, and why faith belongs in the conversation about health at all. They don't agree on everything, and that's the point. For all links mentioned in this episode, visit www.drwillcole.com/podcast.


Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

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