The Art of Being Well
The Art of Being Well

GLP-1 Relationship Killer, Hormone Patches, House Burping, Hashimotos + Autoimmune Anemia | Ask Me Anything

March 19, 2026

AI Summary

5 min read

GLP-1 Relationship Killer, Hormone Patches, House Burping, Hashimoto's + Autoimmune Anemia

The episode opens with a striking clinical observation: about half of people who have heart attacks and strokes have normal to low cholesterol. This sets the tone for an episode that repeatedly challenges conventional medical assumptions, urging listeners to look beyond surface-level lab markers and ask why the body is doing what it's doing.

Cholesterol in Context: Beyond the Number

A listener with PCOS, Hashimoto's, and a family history of high cholesterol asks how to lower LDL naturally. Dr. Will Cole and his clinical team push back hard against the reflex to treat a number. Total cholesterol above 200, they argue, is a poor predictor of cardiovascular risk on its own. What matters more is the quality of the cholesterol-carrying particles. An NMR test can distinguish between large buoyant LDL particles (the "fluffy cotton balls" that are cardioprotective) and small dense LDL particles (the "rusted BB bullets" that drive inflammation and oxidation). The goal is Pattern A, not Pattern B.

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What you'll learn

  • 1 (00:59) **Episode Introduction & Giveaway Details** - Dr. Will Cole introduces the Ask Me Anything format and explains how to win a clinical case review, signed book, or supplement protocol stack.
  • 2 (05:05) **High Cholesterol with PCOS and Hashimoto's** - Michaela asks how to lower LDL naturally when genetics, PCOS, and Hashimoto's are involved.
  • 3 (27:41) **Pernicious Anemia and Low Ferritin** - A listener asks how to raise ferritin while having pernicious anemia.
  • 4 (41:05) **Spot Bleeding After Missing an Estradiol Patch** - Lisa asks if missing one day of her patch can cause spotting.
  • 5 (45:17) **Hot Topic: "Burping Your House" (Stoßlüften)** - Dr. Cole explains the German practice of shock ventilation for indoor air quality.
  • 6 (51:19) **Hot Topic: Do GLP-1 Agonists Kill Romantic Relationships?** - Discussing the theory that GLP-1 drugs blunt dopamine pleasure centers, potentially reducing romantic interest.
  • 7 (57:29) **Listener Review Shout-Out & Sign-Off** - Dr. Cole reads a three-star review criticizing the show's banter, then defends the podcast's style.

+ Full timestamped outline available in the app

Guests on this episode

Dr. Will Cole

Show Notes

In this Ask Me Anything episode, Dr. Will Cole and his clinical team answer listener questions on high LDL and what labs give a clearer picture than total cholesterol alone. They unpack how PCOS, Hashimoto’s, and liver function can influence lipid markers and what to ask your doctor to run. They also cover low ferritin with pernicious anemia, B vitamin labs, and why absorption matters just as much as what you take. Plus: missed estradiol patches and spotting, “burping your house” for healthier indoor air, and a social media debate on GLP-1 medications. For all links mentioned in this episode, visit www.drwillcole.com/podcast


Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

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