The Art of Being Well
The Art of Being Well

Calming Mast Cell Activation Syndrome (MCAS), Histamine Peptides, Ozempic Butt, Burnout & Creatine | Ask Me Anything

October 15, 2026

AI Summary

5 min read

In a 2025 case series published in the American Journal of Medical Sciences, 89% of people with mast cell activation syndrome (MCAS) who were put on GLP-1 receptor agonists saw remission of their symptoms. That finding, from a small study of 47 people, cuts against the widespread fear that peptides are dangerous for anyone with histamine issues. Dr. Will Cole, joined by his clinical team, uses this Ask Me Anything episode to walk through the nuance of peptides and MCAS, the reality of “Ozempic butt,” and whether millennials are resilient or just burnt out.

Peptides and Mast Cell Activation: Fear vs. Mechanism

The first question comes from a listener with MCAS who worries that peptides like BPC-157 will trigger a flare. Dr. Cole’s response is careful: histamine intolerance is a “pseudoallergy,” not a true IgE-mediated allergy. It is a failure of the mast cells to calm down after releasing histamine. The root cause varies—mold, chronic Lyme, SIBO, unresolved trauma—and so does the response to any intervention.

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What you'll learn

  • 1 Timestamped Outline
  • 2 (00:06) **Episode & Giveaway Intro** - Dr. Will Cole opens the Ask Me Anything episode and explains how listeners can submit questions and win prizes.
  • 3 (03:02) **Question 1: Peptides & MCAS Safety** - Brittany asks whether people with Mast Cell Activation Syndrome (MCAS) can safely use peptides without causing flares.
  • 4 (05:46) **Mast Cell Biology & Why Peptides Can Help** - Dr. Cole explains how mast cells work and why certain peptides may actually benefit people with histamine intolerance.
  • 5 (09:28) **Which Peptides Work for MCAS** - Specific peptide recommendations for histamine intolerance, including BPC-157 and stacking options.
  • 6 (11:43) **Mast Cell Stabilization Support** - Dr. Cole recommends supplements that calm mast cells before or alongside peptide therapy.
  • 7 (13:46) **The Fear Factor in MCAS** - The team discusses how trauma and fear around supplements can create physiological responses that mimic allergic reactions.

+ Full timestamped outline available in the app

Guests on this episode

Dr. Will Cole

Show Notes

It's an Ask Me Anything episode - Dr. Will Cole, Emily and Andrea tackle three listener questions: whether peptides like BPC-157 are safe for people with histamine intolerance and MCAS, whether creatine can offset the muscle loss that comes with GLP-1s like Ozempic, and whether any generation alive today is actually resilient or just chronically dysregulated. Plus, Heal Your Cells just hit the New York Times bestseller list. For all links mentioned in this episode, visit www.drwillcole.com/podcast


Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

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