Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like

Bryan Johnson joined the All-In podcast to discuss his extreme longevity project, Blueprint, and recent experiments with psychedelics like psilocybin and 5-MeO-DMT. He frames these as evidence-based interventions to reverse aging, starting from exhaustive reviews of published science on exercise, nutrition, sleep, and progressing to novel therapies. Psychedelics entered his protocol after mouse data on psilocybin suggested rejuvenation potential, despite their traditional use for mental health rituals rather than anti-aging.

Evidence from Psilocybin Trials

Johnson conducted the most quantified human psilocybin experiment, taking three clinical-to-hero doses of 25 mg, measured via Kernel brain interface, MRIs, and other tools. It dampened the default mode network (DMN)—the brain's rumination engine that builds rigid ego patterns, self-doubt, and narrow adult perspectives, which strengthen with age unlike in children. Brain scans showed scrambled connectivity: like repositioning airports globally, weakening over-trafficked "ruts" (e.g., New York-London flights) and enabling random neuron firing for neuroplasticity—new connections fostering fresh behaviors and reduced trauma/anxiety.